Agenda

Agenda

                           Stroke Prevention in the New Decade: Current Status and Unmet Needs

*Preliminary Program

7:00 – 8:00 am

RAISE I Chairperson: M. Edip Gurol (Neurology, MGH/HMS)

Co-Chairs: Jin-Moo Lee (Neurology, Wash U. St-Louis), Jose G. Merino(Neurology, Georgetown U, DC)

8:15-8:27 am
UNDERSTANDING INTRACEREBRAL HEMORRHAGE RISK AND ITS RELEVANCE IN STROKE PREVENTION
Alvin S. Das
(Neurology, MGH/HMS)

8:27-8:39 am
PLASMA BIOMARKERS OF STROKE RISK AND ETIOLOGY
Hooman Kamel
(Neurology, Cornell)

8:39-8:51 am
COGNITION AS AN OUTCOME MEASURE IN STROKE PREVENTION TRIALS
Rebecca Gottesman
(NINDS)

8:51-9:03 am
HOW TO INCORPORATE IMAGING MARKERS IN STROKE PREVENTION TRIALS
Jonathan Graff-Radford
(Neurology, Mayo Clinic Rochester)

9:03-9:15 am
NOVEL TREATMENT TARGETS IN CEREBRAL SMALL VESSEL DISEASES
Steven M. Greenberg
(Neurology, MGH/HMS)

9:15-10:05
DISCUSSION
Paul Ziegler (Medtronic), Rafael Cavalcante (Boston Scientific);TBA

10:05-10:25 am

BREAK

Co-Chairs: Jennifer Majersik (Neurology, Univ. Utah), Christine M. Albert (Cardiac EP, Cedars Sinai)

10:25-10:37 am
AFIB DETECTION AND THE RELEVANCE OF AFIB LOAD
Lee H. Schwamm
(Neurology, MGH/HMS)

10:37-10:49 am
LEFT ATRIAL APPENDAGE: ANATOMY, FUNCTION AND ITS ROLE IN AFIB-RELATED EMBOLISM
Shadi Yaghi
(Neurology, NYU Neurology)

10:49-11:01 am
LEFT ATRIAL APPENDAGE CLOSURE FOR STROKE PREVENTION IN AFIB
Vivek Reddy
(Cardiac EP, Mount Sinai, NYC)

11:01-11:13 am
EMERGING APPROACHES: AFIB ABLATION, CARDIAC IMAGING
Moussa Mansour
(Cardiology, MGH/HMS)

11:13-11:25 am
IMPACT OF ATRIAL FIBRILLATION GENETICS ON DETECTION AND STROKE PREVENTION
Bradford Worrall
(Neurology, Univ. Virginia)

11:25am -12:15pm
DISCUSSION
TBA, Patrice Desvigne-Nickens (NHLBI), Ahmed Elmouelhi (AtriCure); Ian Meredith (Boston Scientific); Christopher Piorkowski (ABBOTT)

12:15-1:15 pm

LUNCH

Co-Chairs: Bruce Ovbiagele (Neurology, UCSF/SFVAHCS), Joseph Broderick (Neurology, Univ. Cincinnati)

1:15-1:27 pm
PFOS AND THEIR CLOSURE: WHAT OTHER DATA ARE NEEDED?
Jeff Saver
(Neurology, UCLA)

1:27-1:39 pm
SURGICAL MEASURES FOR STROKE PREVENTION: FROM LAA CLIPPING TO PROTECTIVE DEVICES
Christopher R. Ellis
(Cardiology, Vanderbuilt University)

1:39-1:51 pm
ADVANCES IN PLATELET AGGREGATION INHIBITORS FOR STROKE PREVENTION
Gregory W. Albers
(Neurology, Stanford Univ.)

1:51-2:03 pm
UPDATES ON LARGE VESSEL DISEASE TREATMENT: CREST-2 AND BEYOND
James Meschia
(Neurology, Mayo Clinic, Jacksonville)

2:03-2:15 pm
RUNNING PRAGMATIC TRIALS & IMPLEMENTATION STUDIES IN AHA’S GWTG
Jonathan Piccini
(Cardiac EP, Duke)

2:15-3:05 pm
DISCUSSION
TBC, Nicole Sur (Neurology, Univ. Miami), Magdy Selim (Neurology, BIDMC/HMS), , Dan Gutfinger (ABBOT), Tom Biggerstaff (Gore Medical), Narinder Bhalla (Astra Zeneca)

3:05-3:25 pm

BREAK

Co-Chairs: Louise McCullough (Neurology, Univ Texas Houston), Kevin Sheth (Neurology, Yale)

3:25-3:37 pm
SEX AND RACE DIFFERENCES IN STROKE PREVENTION: ISSUES RELEVANT TO CLINICAL TRIALS AND PRACTICE
Anjail Sharrief
(Neurology, Univ Texas Houston)

3:37-3:49 pm
NOACS BEYOND NVAF AND DVT: WHAT HAVE WE LEARNED FROM COMPASS & ESUS STUDIES
Ralph Sacco
(Neurology, Univ Miami)

3:49-4:01 pm
FACTOR XI INHIBITORS
C. Michael Gibson
(Cardiology, BIDMC, Boston, MA)

4:01-4:13 pm
PCSK9 INHIBITORS FOR STROKE PREVENTION: CURRENT STATUS AND FUTURE DIRECTIONS
Seeman Chaturvedi (Neurology, University of Maryland, Baltimore, USA)

4:13-4:25 pm
HOW TO DESIGN A TRIAL TO ACHIEVE FDA APPROVAL FOR A NEW INDICATION
Andrew Farb
(FDA)

4:25-5:15 pm
DISCUSSION
Clinton B. Wright
(NINDS), Larry Goldstein (U Kentucky, KY), John Venditto (Astra Zeneca) TBA

6:30 – 7:30 pm

COCKTAIL RECEPTION

7:30 – 9:30 pm

DINNER BANQUET

FOLLOWED BY SPECIAL PRESENTATIONS

WSO AND STROKE PREVENTION
Marc Fisher
(Neurology, BIDMC/HMS)

PREVENTION OF STROKE AND VASCULAR COGNITIVE IMPAIRMENT: PRIORITIES FOR NINDS
Walter Koroshetz
(Director, NINDS)

7:00 – 8:00 am

Participants are divided into three groups – each to develop recommendations

Workshop #1
HOW TO DESIGN STROKE PREVENTION TRIALS IN REAL WORLD ATRIAL FIBRILLATION PATIENTS
Jonathan Hsu
(Cardiac EP, USCD, CA), Eric Smith (Neurology, Univ. Calgary), Mariel Kozberg (Neurology, MGH/HMS)

Workshop #2
STROKE RISK FACTOR MANAGEMENT IN 2020S: WHAT DO WE KNOW? WHAT OTHER DATA DO WE NEED?
Cheryl Bushnell
(Neurology, Wake Forest), Amy Towfighi (Neurology, USC/LAC)

Workshop #3:
NON-CARDIOEMBOLIC STROKE PREVENTION: NEW DEVICES AND DRUGS
Luciano Sposato
(Neurology, Western University, London, ON, CA), Sean Savitz (Neurology, UT Houston)

10:30 – 10:45 am

DRAFTING OF CONSENSUS STATEMENT IS INITIATED
Chaired by M. Edip Gurol
(MGH/HMS)